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. 2017 Nov 22;8:180–188. doi: 10.1016/j.molmet.2017.11.010

Figure 4.

Figure 4

Increased thermogenesis in Cadm2-deficient Lepob/obmice. A, Core body temperature in 12-week-old mice (n = 4–16). B, Inguinal WAT (ingWAT) and liver mass in 12-week-old mice (n = 3–5). C, Western blot analysis of interscapular BAT extracts from 12-week-old wild-type (WT), Lepob/ob mice and Cadm2/ob mice using antibodies against Cadm2, Ucp1, tyrosine hydroxylase (TH) and α-tubulin. D–F, Haematoxilin and eosin staining of interscapular BAT, ingWAT, and liver and qRT-PCR gene expression analysis from 12-week-old wild-type (WT), Lepob/ob mice and Cadm2/ob mice (n = 3–6). Results are presented as mean ± SEM. *P < 0.05, **P < 0.01 and ***P < 0.001.