Table 1.

Reported Force-Dependent Responses of Collagen’s Triple Helix for Forces below 10 pN

Force Response	Technique Used
Stabilizes/tightens	force-dependent cleavage with bacterial collagenase (14)
	steered molecular dynamics (6)
No change (entropically extends)	optical tweezers stretching (12)
	steered molecular dynamics (6)
	force-dependent cleavage with bacterial collagenase (15)
Destabilizes/unwinds/lengthens	force-dependent cleavage with MMP1 (9, 15)
	optical tweezers stretching (13)
Shears open	steered molecular dynamics (10)