Table 1.
Values (median and IQR) of measured serum parameters for each experimental group at study entry and after 3 months.
| Examined parameter | Experimental groups | ||
|---|---|---|---|
| Controls | ATV | ATV + vitEC | |
| At study entry | |||
| AST (U/l) | 23.7 (16.4–28.7) | 42.7 (28.7–48.2) (p=0.009∗) | 41.5 (32.5–53.5) (p=0.002∗) |
| ALT (U/l) | 20.2 (14.5–28.4) | 41.9 (29.8–69.7) (p=0.002∗) | 49.7 (39.1–67.8) (p < 0.001∗) |
| CRP (mg/l) | 0.8 (0.3–1.6) | 6.2 (5.6–8.3) (p < 0.001∗) | 6.9 (5.1–9.8) (p < 0.001∗) |
| TG (mmol/l) | 1.2 (0.9–1.5) | 3.2 (1.3–6.3) (p=0.018∗) | 3.4 (1.6–5.5) (p=0.039∗) |
| TC (mmol/l) | 4.6 (3.0–5.7) | 7.6 (6.6–8.7) (p=0.006∗) | 6.5 (5.9–7.3) (p=0.020∗) |
| LDL-C (mmol/l) | 2.4 (1.6–3.2) | 6.0 (4.5–6.9) (p=0.002∗) | 5.1 (4.3–5.9) (p=0.004∗) |
| HDL-C (mmol/l) | 1.5 (1.0–1.9) | 0.7 (0.3–1.4) (p=0.047∗) | 0.6 (0.3–0.9) (p=0.029∗) |
| After 3 months | |||
| AST (U/l) | 17.4 (15.0–24.1) | 24.2 (20.1–25.3) (p=0.044†) | 23.1 (18.7–33.7) (p=0.040†) |
| ALT (U/l) | 23.8 (20.3–29.7) | 30.8 (22.5–36.8) (p=0.004†) | 31.2 (26.7–35.3) (p=0.002†) |
| CRP (mg/l) | 1.1 (0.8–1.5) | 3.2 (2.9–3.8) (p=0.003∗, p=0.031†) | 3.1 (2.2–3.6) (p=0.011∗, p=0.004†) |
| TG (mmol/l) | 1.8 (0.9–2.2) | 1.3 (1.0–2.1) (p=0.002†) | 1.2 (1.0–1.7) (p=0.007†) |
| TC (mmol/l) | 4.8 (4.7–4.9) | 4.8 (3.9–5.2) (p=0.009†) | 5.7 (3.8–6.9) |
| LDL-C (mmol/l) | 3.5 (2.2–3.9) | 3.2 (2.9–3.4) (p=0.016†) | 3.2 (3.1–3.3) (p=0.010†) |
| HDL-C (mmol/l) | 1.2 (0.5–1.7) | 1.5 (0.7–1.7) | 1.6 (1.1–1.8) (p=0.015†) |
∗Comparing marked group versus control at the same time point; †comparing marked group versus same group at the study entry; only cases where p < 0.05 are marked.