Skip to main content
. Author manuscript; available in PMC: 2019 Mar 1.
Published in final edited form as: J Thorac Cardiovasc Surg. 2017 Nov 29;155(3):1118–1127.e1. doi: 10.1016/j.jtcvs.2017.08.127

Figure 1.

Figure 1

The neonatal heart regenerates with minimal fibrosis after apical resection. A, Masson's trichrome staining of hearts at 0, 11, and 30 days postresection. For comparison, sham-operated hearts, harvested 30 days after surgery, are included. A magnified image of each apex is provided below. An apical thrombus quickly formed after resection and became fibrotic by 11 days postresection. By 30 days postresection, the heart had regenerated with minimal fibrosis. B, Quantification of fibrotic area in the apex after apical resection at 11, 14, 21, and 30 days postresection. For comparison, sham-operated hearts harvested 30 days after surgery are included. Values are represented as percentage fibrosis of the apical area. Fibrosis in the apex consistently decreased over time. This suggests that fibrosis is gradually replaced by myocardium as heart regeneration progresses. Red bars represent median value for each timepoint. Asterisks denote statistical significance at **P < .01.