| Alzheimer disease |
ATF4 |
Aβ1-42 induced transcription and anterograde transport |
(Baleriola and others 2014) |
| Amyotrophic lateral sclerosis (ALS) |
Nefl |
Decreased transport with TDP-43 mutation |
(Alami and others 2014) |
|
271 decreased + 176 increased |
Altered axonal localization with TDP-43A315T expression |
(Rotem and others 2017) |
|
80 decreased + 95 increased |
Altered axonal localization with SOD1G93A expression |
|
|
APC mRNA ligands |
Altered axonal localization with FUS/TLS expression |
(Yasuda and others 2017) |
|
| Spinal Muscular Atrophy (SMA) |
β-actin, GAP43, Cav2.2 |
Decreased axonal levels with SMN depletion |
(Fallini and others 2016; Jablonka and others 2007) |
|
Increased and decreased mRNAs |
SMN depletion from motor neurons substantially alters the axonal transcriptome |
(Saal and others 2014) |
|
| Neuropathic pain |
CREB1 |
Capsaicin and IL-6 injection increase intra-axonal translation through mTOR pathways |
(Melemedjian and others 2010; Melemedjian and others 2013; Melemedjian and others 2014) |
|
| Neurotropic viral infection |
? |
Retrograde transport of pseudorabies virus requires axonal translation |
(Koyuncu and others 2013) |
