Fig. 11.

(a, b) Schematic illustrations of the rational design and combinatorial synthesis of telodendrimers for systematic evaluation and optimization for (a) drug delivery and (b) protein delivery. (c) Unbound interaction energy computed from molecular dynamics simulations plotted against the minimum docking energies. (d) The binding enthalpies analyzed by a solvent-balance method were plotted against the lowest docking energies. (e) Natural logarithm of equilibrium dissociation constant (lnK_D) plotted against average docking energy (E_a). Linear regression was fit via Ordinary Least Square to calculate the Pearson correlation coefficient r and the associated P values for c, d and e. (f) Quantification of hypoglycemia index. Reproduced with permissions from ref. [17] and [31]. Copyrights to Nature Publishing Group and the American Chemical Society.