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. 2018 Feb 9;10:39–54. doi: 10.1016/j.molmet.2018.01.023

Figure 9.

Figure 9

PPARγ activation but not PPARα activation is able to markedly upregulate cold-induced genes in murine WAT. A) Relative gene expression of Pparg in gonadal WAT and inguinal WAT of wildtype mice after 10 days at 28 °C (warm, n = 6–8) or 5 °C (cold, n = 10) [51]. Data are presented as mean ± SEM. Asterisk indicates significantly different from thermoneutral mice according to Student's t-test (**P < 0.01). B) Comparative analysis was performed between whole genome expression changes in WAT in response to 10-day cold exposure and in response to 7-day treatment with rosiglitazone (0.01 % wt/wt of feed) or Wy-14,643 (0.1 % wt/wt of feed). The top 25 most highly induced genes by 10-day cold exposure in WAT of wildtype mice were selected. The effect of 1-week treatment with rosiglitazone or Wy-14,643 on the expression of these genes in WAT of wildtype mice is shown (GSE11295). The top 25 list differs from Figure 7, because certain genes were either not present on the microarray used for the rosiglitazone/Wy-14,643 study or did not meet the filtering criteria.