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Effects of high glucose on the expressions of sirtuin 1 (SIRT1), p53, Ac-p53, and apoptosis-associated proteins. SH-SY5Y cells were cultured in either 5.5 mM (CON) or 75 mM (HG) glucose-containing media for 96 h. (A) Representative Western blot images. (B) Quantifications of SIRT1, p53 (Ac-K382), and p53 expression. (C) Quantifications of caspase-3, Bcl-2, Bax, and Bcl-2/Bax expression. (D) SIRT1 activity. *P < 0.05; **P < 0.01 versus control. N = 3.
