Table 2.
Immune intrigue of colorectal liver metastases patients.
| Cell type | Location | Role | Prognosis |
|---|---|---|---|
| T cell (CD4+ and CD8+) | Intratumoral; invasive margin | Specific tumor cell killing activity Release cytotoxic cytokines |
+ |
| Treg | Intratumoral; invasive margin | Suppress anticancer immune responses | − |
| Macrophage | Intratumoral; invasive margin | M1: tumor suppression and immune stimulation M2: malignant progression and suppressed CTL |
+/− |
| NK | Intratumoral; invasive margin | Cytotoxic activity and cytokine production | + |
| MDSC | Intratumoral; invasive margin | Repression of the effector function of T lymphocytes and NK cells |
− |
| DC | Intratumoral; invasive margin | Processing and presentation of tumor-associated antigens | + |
Treg, T regulatory; CTL, cytotoxic T lymphocytes; NK, natural killer; MDSC, myeloid-derived suppressor cell; DC; dendritic cells.