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. 2018 May 28;9:950. doi: 10.3389/fmicb.2018.00950

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Copyright © 2018 Greene, Kaplan, Crow and Koronakis.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A molecular bellows mechanism for the MacAB-TolC pump driven by mechanotransmission. The proposed catalytic cycle of the MacAB-TolC efflux pump (Top) is shown in comparison with the operation of a fireplace bellows (Bottom). Substrates are driven out by mechanotransmission-induced changes in the MacB periplasmic domains and prevented from flowing back into the periplasm by a valve in MacA. The individual pump components are colored: MacB (red), MacA (purple), TolC (green) and substrate (blue). Adapted from Crow et al. (2017).