Figure 1.

Fine-Mapping Identifies a Single Signal Consisting of a Cluster of 16 Highly Linked Variants Associated with High Proinsulin Levels

(A) Locus Zoom plot showing the association between genetic variants and increased proinsulin levels in the VPS13C-C2CD4A-C2CD4B locus in the METSIM study population. The index SNP (rs7172432) is purple. The x axis displays the gene and variant position on chromosome 15 (chr15) in megabases (Mb). The y axis indicates association p values (left) and recombination rates (right) in centiMorgans (cM). Associated variants reside between two intergenic recombination hotspots (blue peaks) between C2CD4A and C2CD4B.

(B) Locus Zoom plot of proinsulin association in the locus after conditioning on rs7172432. The x and y axes are as described in (A).