Figure 3.

Split Decomposition Networks of Sickle-Carrying Haplotypes

(A) Network of 20 distinct sickle-carrying haplotypes, rooted by the ancestral haplotype. The haplotypes are defined in Table 4. The single branch leading from the ancestral root is the only branch to which the sickle mutation contributes, indicating a single origin of the sickle mutation. The scale bar represents 0.01 mutations/site.

(B) The subnetwork showing the ancestral root and the three modal haplotypes. This subnetwork emphasizes that HAP16 and HAP20 share a common ancestor and that this common ancestor is derived from HAP1. The scale bar represents 0.1 mutations/site.