Table 1.
Molecular Characterization of the Classical Sickle Haplotypes
|
Site |
||||
|---|---|---|---|---|
| 3′ ψβ HincII | Aγ1 HindIII | Gγ1 HindIII | 5′ ε HincII | |
| Sequencea | GTTGAC | AAGCTT | AAGCTT | GTTGAC |
| Range | 5,260,457–5,260,462 | 5,269,799–5,269,804 | 5,274,717–5,274,722 | 5,291,563–5,291,567 |
| rsID | rs968857 | rs28440105 | rs2070972 | rs3834466 |
| Position (hg19) | 5,260,458 | 5,269,799 | 5,274,717 | 5,291,563–5,291,564 |
| Senegal | + | − | + | − |
| Benin | + | − | − | − |
| CAR | − | − | + | − |
| Cameroon | + | + | + | − |
| Arabian/Indian | + | − | + | + |
| r2b | 0.000 | 0.016 | 0.003 | 0.020 |
| D′b | −0.104 | 0.930 | 0.094 | −0.853 |
| Ancestral | T | C | C | G |
| Status | + | − | − | − |
| Derived | C | A | A | GT |
| Status | − | + | + | + |
a
Underlining indicates the polymorphic position.
b
Pairwise linkage disequilibrium values are shown with respect to rs334.