Table 4.
Distribution of Sickle Haplotypes under a Sequence-Based Classification Scheme Using 27 Markers
| Name | Haplotypea | Arabian/Indian | Benin | Cameroon | CAR | Senegal | Atypical |
|---|---|---|---|---|---|---|---|
| Ancestor | 0000000000000000000000000010 | NA | NA | NA | NA | NA | NA |
| HAP1 | 0000000000000000000010000010 | 1 | 0 | 2 | 37 | 0 | 1 |
| HAP2 | 0000000000000000000010110010 | 0 | 4 | 0 | 0 | 0 | 0 |
| HAP3 | 0000000000000000000010110101 | 0 | 0 | 0 | 0 | 1 | 0 |
| HAP4 | 0000000000000000001110110101 | 0 | 2 | 0 | 0 | 0 | 0 |
| HAP5 | 0000000000000000111110110101 | 0 | 5 | 0 | 0 | 0 | 0 |
| HAP6 | 0000000000000001100011001010 | 0 | 0 | 0 | 0 | 3 | 0 |
| HAP7 | 0000000100000100111110110101 | 0 | 1 | 0 | 0 | 0 | 0 |
| HAP8 | 0000000100000100111110110110 | 0 | 0 | 0 | 0 | 1 | 0 |
| HAP9 | 0000111011111011100011001010 | 0 | 0 | 0 | 0 | 1 | 0 |
| HAP10 | 0001000000000000000010000010 | 0 | 0 | 0 | 1 | 0 | 0 |
| HAP11 | 0001000100000100111110110101 | 0 | 2 | 0 | 0 | 1 | 0 |
| HAP12 | 0011000100000100101110000010 | 0 | 0 | 0 | 0 | 1 | 0 |
| HAP13 | 0011000100000100111110000010 | 0 | 1 | 0 | 0 | 0 | 1 |
| HAP14 | 0011000100000100111110110010 | 0 | 0 | 0 | 0 | 1 | 0 |
| HAP15 | 0011000100000100111110110100 | 0 | 2 | 0 | 0 | 1 | 0 |
| HAP16 | 0011000100000100111110110101 | 0 | 23 | 0 | 0 | 7 | 0 |
| HAP17 | 0011000100000100111110110110 | 0 | 6 | 0 | 0 | 5 | 0 |
| HAP18 | 0011000100000100111110110111 | 0 | 1 | 0 | 0 | 0 | 0 |
| HAP19 | 1100111011111011100010000010 | 0 | 0 | 0 | 0 | 3 | 1 |
| HAP20 | 1100111011111011100011001010 | 0 | 0 | 0 | 0 | 36 | 0 |
a
0 indicates the reference allele, and 1 indicates the alternate allele according to the coding scheme in the 1000 Genomes Project VCF files. The sickle site rs334 is underlined.