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. 2018 May 28;9:1191. doi: 10.3389/fimmu.2018.01191

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Copyright © 2018 Machida, Sakamoto, Ishida, Takahashi, Fujita and Sekine.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Assessment of glomerular (A) and renal interstitial (B) pathologies stained with hematoxylin and eosin. Glomerular pathology was graded from the sum of scores for glomerular inflammation, thickness of basement membrane, epithelial cell reactivity, crescent formation, and necrosis. Interstitial pathology was graded using the sum of scores for perivascular inflammation and inflammatory cell infiltration. Scores were graded as 0 to 4+ (0, none; 1+, mild; 2+, moderate; 3+, moderate-high; 4+, high). Original magnification 200× for glomerular pathology, and 40× for interstitial pathology.