Table 2.
Representative modeling studies of hepatitis C virus envelope glycoproteins and receptors.
| Target | Model | Methodsa | Year | Reference |
|---|---|---|---|---|
| E2 | Structure | Homology-based modeling | 2000 | (61) |
| E2 | Structure | Homology-based modeling, disulfide mapping | 2010 | (62) |
| E2-CD81 | Complex structure | Restraints-guided docking | 2013 | (47) |
| E2 | Front layer dynamics | Molecular dynamics simulation | 2016 | (36) |
| E1E2 transmembrane | E1 trimerization, E1E2 heterohexamer | Docking with restraints | 2015 | (63) |
| E1E2 | Structure | Evolutionary constraints-based structure prediction, homology-based modeling, experimental mapping residue constraints | 2017 | (64) |
| E1E2 | Structure, high order assembly | Homology-based modeling, ab initio structure prediction, experimental mapping residue constraints, docking | 2017 | (65) |
| SR-BI | Structure | Homology-based modeling | 2013 | (66) |
| CD81-Claudin | Structure | Homology-based modeling, docking | 2012 | (67) |
aSummary of modeling methods used.