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. 2018 May 28;9:149. doi: 10.3389/fpsyt.2018.00149

Figure 5.

Figure 5

Effect of methylphenidate, 3,4-CTMP and ethylphenidate in the nucleus accumbens (NAc) and bed nucleus of the stria terminalis (BNST) slice. After 3 baseline electrical stimulations (10 pulses at 100 Hz) methylphenidate, 3,4-CTMP or ethylphenidate (EPH) was added at a single concentration (arrow). The drug was left on for 60 min and stimulations continued at 5 min intervals. (A) Effect of 3,4-CTMP in the accumbens. (B) Effect of ethylphenidate in the accumbens. (C) Effect of methylphenidate in the accumbens (D) Comparison of methylphenidate, 3,4-CTMP and ethylphenidate in the accumbens using a two-way ANOVA. Asterisks denote difference between drugs, (E) Effect of 3,4-CTMP in the BNST. (F) Effect of ethylphenidate in the BNST. (G) Effect of methylphenidate in the BNST. (H) Comparison of methylphenidate, 3,4-CTMP and ethylphenidate in the BNST using a two-way ANOVA; there was no significant difference between the three drugs, but there was a significant effect of drug concentrations as denoted by the cross (+). Values are means ± SEM, n = 3–8. *p < 0.05, **p < 0.005, +p < 0.05, ++p < 0.005.