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. 2018 May 28;9:558. doi: 10.3389/fphys.2018.00558

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Copyright © 2018 Schiattarella, Boccella, Paolillo, Cattaneo, Trimarco, Franzone, D’Apice, Giugliano, Rinaldi, Borzacchiello, Gentile, Lombardi, Feliciello, Esposito and Perrino.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Akap1 deficiency exacerbates pressure overload-induced cardiac hypertrophy. (A) Representative immunoblot (left) and densitometric analysis (right) of AKAP121 protein levels in hearts from sham (n = 5) and 1 week transverse aortic constriction (TAC 1w; n = 7) operated wt, Akap1^+/-, and Akap1^-/- mice. GAPDH was used as control of loading sample (^∗p < 0.05 vs. wt sham). (B) Bar graphs showing cumulative data of left ventricular weight (LVW) to body weight (BW) 1 week after sham or TAC procedures in wt, Akap1^+/-, and Akap1^-/- mice (^∗p < 0.05 vs. sham; ^§p < 0.05 vs. wt TAC 1w; n = 7 hearts/group). (C) (Left) Representative images of wheat germ agglutinin (WGA) staining of cardiac transversal sections from wt, Akap1^+/-, and Akap1^-/- mice 1 week after sham or TAC procedure. DAPI was used as nuclei counterstaining. Scale bar: 20 μm. (Right) Bar graphs showing cumulative data of multiple independent experiments analyzing cardiomyocytes cross-sectional area (^∗p < 0.05 vs. sham; ^§p < 0.05 vs. wt TAC 1w; n = 5 hearts/group). (D) mRNA levels of β-myosin heavy chain (β-MHC) in cardiac samples from wt, Akap1^+/-, and Akap1^-/- mice 1 week after sham or TAC procedure (^∗p < 0.05 vs. sham; n = 5 hearts/group).