Figure 2.

Mice Deficient in Otud7a Show Cardinal Phenotypes Related to 15q13.3 Microdeletion Syndrome

Data from male and female mice were combined for behavioral tests performed during pre-weaning period and were shown as bars or lines in purple. Behavioral data from male and female adult mice were shown separately, with males in blue and females in red.

(A) Null mice have decreased body weight prior to weaning.

(B) Null mice show developmental delay.

(C) Null mice show impaired ultrasonic vocalization.

(D) Null mice have reduced grip strength.

(E and F) Both male and female null mice show impairment in rotarod performance.

(G) Homozygous and heterozygous Otud7a knockout mice show reduced acoustic startle response.

(H and I) Male (H) and female (I) null mice manifest deficits in prepulse inhibition.

Data are presented as mean ± SEM (^∗p < 0.05, ^∗∗p < 0.01, ^∗∗∗p < 0.001, ^∗∗∗∗p < 0.0001).