Table 3.

Comparison of Behavioral and Electrophysiological Phenotypes between 15q13.3 Homozygous Knockout Mice and Otud7a-Null Mice

Phenotypes/Behavioral Assays	Df(h15q13)−/−	Otud7a−/−
Body weight	decreased	decreased
Ultrasonic vocalization	impaired	impaired
Acoustic startle	impaired	impaired
Prepulse inhibition	impaired	impaired
Grip strength	decreased	decreased in female, trend toward decrease in male
Seizures/EEG recording	altered seizure response to PTZ administration	spontaneous EEG abnormalities
Open field	no significant change	no significant change
Three-chamber test	no impairment	no impairment
Developmental delay	not assessed	developmental delay
Rotarod performance	not assessed	impaired
Elevated plus maze	not assessed	no significant change
Novel object recognition	not assessed	no significant change
Forced swimming	not assessed	no significant change
Partition test	not assessed	no impairment
Morris water maze	inconclusive due to vision impairment	not assessed due to motor deficits
Nest buildinga	impaired	trend toward impairment but no significant change
Fear conditioning	decreased cued fear memory	no significant change in female, increased cued fear memory in male

Reference for behavioral phenotypes in Df(h15q13)^−/− mice: Forsingdal et al.²⁰

^aIn the Df(h15q13)^−/− study, 6 knockout mice with mixed gender were assessed. In our study, 14 male Otud7a^−/− mice and 16 female Otud7a^−/− mice were assessed.