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Microbiota-derived molecules prevent colonization by pathogens. The microbiota produces molecules that contribute to colonization resistance. (A) Members of the microbiota consume complex polysaccharides and produce SCFAs, which prevent proliferation of and colonization by pathogens. (B) The QS molecule, autoinducer-2 (AI-2), helps the microbiota colonize the gut, which also prevents colonization by pathogens. Additionally, AI-2 negatively affects virulence gene regulation.
