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Wild-type challenge attack rate, vaccine efficacy and complement-mediated bactericidal activity following two immunizations.
| Attack rate following challenge | Efficacy against wild-type | 50% serum bactericidal | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Vaccination | with wild-type strain | challenge | titer | ||||||
| 2457T | J17B | CCH060 | 2457T | J17B | CCH060 | 2457T | J17B | CCH060 | |
| CVD 1208S | 0/4 | – | – | 100% | – | – | 1917 | – | – |
| CVD 1213 | – | 0/4 | – | – | 100% | – | – | 1356 | – |
| CVD 1215 | – | – | 0/4 | – | – | 100% | – | – | 2700 |
| Combination | 1/3 | 0/4 | 0/4 | 67% | 100% | 100% | 4395 | 2344 | 742 |
