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. 2018 Jun 1;32:2058738418772652. doi: 10.1177/2058738418772652

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© The Author(s) 2018

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 5. — BISPR promoted the development of TPC cells by inhibiting miR-21-5p expression. (a) Compared with miR-NC group, the expression level of miR-21-5p in miR-21-5p mimics group was much higher and that in miR-21-5p inhibitor group was much lower. At the meantime, miR-21-5p expression in sh-BISPR + miR-21-5p inhibitor group was much higher than that in miR-21-5p inhibitor group. (b) The iodine uptake of BHT101 and Hth83 cell lines with miR-21-5p mimics was much higher than that in miR-NC group, while that with miR-21-5p inhibitor was lower than that in the miR-NC group. At the same time, the cell iodine uptake in sh-BISPR + miR-21-5p inhibitor group was much higher than that in miR-21-5p inhibitor group. ^*P < 0.05, compared with miR-NC group; ^#P < 0.05, compared with miR-21-5p inhibitor group. (c and d) The cell viability of BHT101 and Hth83 cell lines with miR-21-5p mimics was much lower than that in miR-NC group, while that with miR-21-5p inhibitor was higher than that in miR-NC group. However, cell viability in sh-BISPR + miR-21-5p inhibitor group was lower than that in miR-21-5p inhibitor group. ^*P < 0.05, compared with miR-NC group; ^**P < 0.01, compared with miR-NC group; ^#P < 0.05, compared with miR-21-5p inhibitor group. (e) The number of invasive cells in BHT101 and Hth83 cell lines with miR-21-5p mimics was much lower than that in miR-NC group while that with miR-21-5p inhibitor was higher than that in the miR-NC group. However, the number of invasive cells in sh-BISPR + miR-21-5p inhibitor group was lower than that in miR-21-5p inhibitor group. ^*P < 0.05, compared with miR-NC group; ^#P < 0.05, compared with miR-21-5p inhibitor group.