Table 2.
Change in forced vital capacity, forced expiratory flow at 25%, 50%, 75%, and between 25–75% at week 12: descriptive statistics, full analysis population.
| Predose, change from baseline* |
2 h postdose, change from baseline* |
|||
|---|---|---|---|---|
| n | Mean (SD) | n | Mean (SD) | |
| FVC (l) | ||||
| Fluticasone/formoterol | 156 | 0.128 (0.2743) | 146 | 0.195 (0.2417) |
| Fluticasone | 149 | 0.151 (0.2625) | 148 | 0.193 (0.2679) |
| Fluticasone/ salmeterol | 156 | 0.170 (0.2344) | 153 | 0.196 (0.2544) |
| FEF25 (l/s) | ||||
| Fluticasone/formoterol | 156 | 0.570 (0.8283) | 146 | 0.941 (0.8069) |
| Fluticasone | 149 | 0.335 (0.6711) | 148 | 0.408 (0.6099) |
| Fluticasone/ salmeterol | 156 | 0.564 (0.7583) | 153 | 0.891 (0.7790) |
| FEF50 (l/s) | ||||
| Fluticasone/formoterol | 156 | 0.370 (0.6240) | 146 | 0.714 (0.5995) |
| Fluticasone | 149 | 0.176 (0.4986) | 148 | 0.282 (0.5091) |
| Fluticasone/salmeterol | 156 | 0.382 (0.5313) | 153 | 0.652 (0.5683) |
| FEF75 (l/s) | ||||
| Fluticasone/formoterol | 156 | 0.189 (0.3638) | 146 | 0.343 (0.3832) |
| Fluticasone | 149 | 0.077 (0.3780) | 148 | 0.134 (0.3485) |
| Fluticasone/salmeterol | 156 | 0.164 (0.4016) | 153 | 0.338 (0.4284) |
| FEF25–75 (l/s) | ||||
| Fluticasone/formoterol | 156 | 0.346 (0.5320) | 146 | 0.622 (0.5180) |
| Fluticasone | 149 | 0.139 (0.4583) | 148 | 0.243 (0.4461) |
| Fluticasone/salmeterol | 156 | 0.325 (0.5025) | 153 | 0.578 (0.5248) |
*
Change from predose measurement at the baseline visit.
FEF, forced expiratory flow; FEF25, forced expiratory flow at 25%; FVC, forced vital capacity; SD, standard deviation.