Table 1.
Clinical characteristics of patients grouped by type of BM involvement
| Characteristics | Negative BM (n = 449) No. (%) | Concordant BM (n = 173) No. (%) | Discordant BM (n = 90) No. (%) |
P value
|
Advanced DLBCL & Negative BM (n = 212) No. (%) |
P value
|
|||
|---|---|---|---|---|---|---|---|---|---|
| Neg v Con | Neg v Dis | Con v Dis | Adv-Neg v Con | Adv-Neg v Dis | |||||
| Age (years) | |||||||||
|
| |||||||||
| Median | 62.6 | 63.0 | 63.0 | 0.841 | 0.715 | 0.838 | 62.0 | 0.950 | 0.814 |
|
| |||||||||
| Range | 16–89 | 25–91 | 31–89 | 17–89 | |||||
| Sex | |||||||||
|
| |||||||||
| Male | 267 (59.5) | 81 (46.8) | 54 (60.0) | 0.004 | 0.925 | 0.042 | 123 (58.0) | 0.029 | 0.749 |
|
| |||||||||
| Female | 182 (40.5) | 92 (53.2) | 37 (40.0) | 89 (42.0) | |||||
| IPI factors | |||||||||
|
| |||||||||
| Age >60 years | 255 (56.8) | 101 (58.4) | 51 (56.7) | 0.720 | 0.982 | 0.789 | 121 (57.1) | 0.911 | 0.948 |
|
| |||||||||
| LDH elevated | 240 (57.4) | 138 (80.2) | 34 (38.2) | <0.001 | 0.001 | <0.001 | 134 (66.0) | 0.003 | <0.001 |
|
| |||||||||
| Stage III–IV | 212 (47.9) | 173 (100.0) | 90 (100.0) | <0.001 | <0.001 | 1.000 | 212 (100.0) | 1.000 | 1.000 |
|
| |||||||||
| ECOG PS ≥2 | 53 (12.8) | 63 (36.6) | 10 (11.2) | <0.001 | 0.691 | <0.001 | 39 (19.7) | <0.001 | 0.078 |
|
| |||||||||
| Extranodal sites >1 | 63 (14.1) | 115 (66.5) | 55 (61.1) | <0.001 | <0.001 | 0.388 | 61 (28.9) | <0.001 | <0.001 |
|
| |||||||||
| IPI score | |||||||||
|
| |||||||||
| Low (0–1) | 173 (39.9) | 6 (3.5) | 11 (12.4) | <0.001 | <0.001 | <0.001 | 21 (10.2) | <0.001 | 0.861 |
|
| |||||||||
| Intermediate (2–3) | 214 (49.3) | 85 (49.4) | 58 (65.1) | 138 (67.4) | |||||
|
| |||||||||
| High (4–5) | 47 (10.8) | 81 (47.1) | 20 (22.5) | 46 (22.4) | |||||
|
| |||||||||
| Bulky mass ≥7cm | 108 (28.5) | 50 (30.1) | 28 (31.1) | 0.700 | 0.623 | 0.869 | 60 (32.8) | 0.586 | 0.781 |
|
| |||||||||
| B symptoms | 141 (32.4) | 100 (58.1) | 18 (20.0) | <0.001 | 0.02 | <0.001 | 97 (46.6) | 0.028 | <0.001 |
Abbreviations: Neg, negative BM involvement; Con, concordant BM involvement; Dis, discordant BM involvement; Adv-Neg, advanced DLBCL with negative BM involvement