Table 4.
Associations between all forms of psychosocial adversity and methylation age acceleration (unadjusted)
| ALSPAC 29-year data | ALSPAC 47-year data | NSHD at 53 years | |
|---|---|---|---|
| (n = 989) | (n = 989) | (n = 773) | |
| Mean difference in methylation age acceleration (years) (95% CI) | |||
| Parental physical illness | −0.37 (−1.11, 0.38) | 0.11 (−0.68, 0.90) | −0.61 (−1.51, 0.29) |
| Parental absence | 0.22 (−0.68, 1.13) | −0.04 (−0.99, 0.90) | 0.76 (−1.90, 3.42) |
| Childhood physical illness | −0.71 (−2.27, 0.84) | 0.09 (−1.52, 1.69) | 0.07 (−1.09, 1.22) |
| Parental mental illness | −0.79 (−1.56, −0.03) | −0.03 (−0.79, 0.74) | 2.41 (−0.59, 5.42) |
| Sub-optimal maternal bonding | −0.10 (−1.09, 0.88) | −0.13 (−1.10, 0.84) | −0.04 (−1.08, 1.01) |
| Parental divorce/separation | 0.28 (−0.71, 1.27) | −0.56 (−1.60, 0.47) | −0.97 (−2.68, 0.74) |
| Parental death | 0.72 (−0.87, 2.30) | 0.29 (−1.33, 1.91) | −0.26 (−1.82, 1.30) |
| Child maltreatment | 0.05 (−0.76, 0.86) | 0.12 (−0.76, 1.01) | −1.26 (−2.93, 0.41) |
| Adoption | 0.17 (−2.00, 2.34) | −0.85 (−3.13, 1.43) | n/a |
| Physical cruelty | 0.84 (−1.04, 2.72) | 0.15 (−1.81, 2.12) | n/a |
| Emotional cruelty | −0.28 (−1.52, 0.95) | −0.32 (−1.61, 0.96) | n/a |
| Physical neglect | −0.83 (−3.60, 1.95) | −2.06 (−5.40, 1.27) | n/a |
| Emotional neglect | 0.28 (−0.57, 1.13) | −0.12 (−1.01, 0.77) | n/a |
| Spent time in care | −0.35 (−3.44, 2.75) | −1.43 (−4.72, 1.86) | n/a |
| Poor family function | 0.91 (−0.13, 1.95) | −0.48 (−1.71, 0.74) | n/a |
| Sexual abuse | 2.74 (0.93, 4.56) | 3.34 (1.47, 5.22) | n/a |