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. 2018 May 28;9:245. doi: 10.3389/fendo.2018.00245

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Copyright © 2018 Post, Karashchuk, Wade, Sajid, De Meyts and Tatar.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Glycogen phosphorylase (GlyP) phosphorylation is required for longevity conferred by mutation of dilp2. Survival calculated from life tables based on estimated Gompertz mortality parameters for UAS-GlyP expression in a dilp2 mutant background with transgenes driven by systemic DaGS-Gal4. Gompertz mortality scale (l, frailty) parameters of transgene expression genotypes were adjusted for the impact of RU alone upon mortality estimated from control genotypes. (A) Overexpression of wild-type GlyP does not extend longevity (Cox hazard analysis, χ² = 0.1, p = 0.76), (B) expression of GlyP S15A decreases lifespan (Cox hazard analysis, χ² = 24.2, p < 0.0001), and (C) expression of GlyP S15D does not extend longevity (Cox hazard analysis, χ² = 1.2, p = 0.28). Each genotype cohort n = 351–361 adults.