Table 1.
Relationship between MUC1 expression and clinical features in 486 PTC patients from TCGA database
| Characteristics |
MUC1
|
P-value | |
|---|---|---|---|
| High expression
|
Low expression
|
||
| n=243 | n=243 | ||
| Size (cm) | 2.79±1.81 | 2.64±1.66 | 0.356 |
| Age (years) | 47.69±16.21 | 46.85±15.34 | 0.558 |
| BRAF mutation | <0.001 | ||
| Yes, n (%) | 203 (83.5) | 76 (31.3) | |
| No, n (%) | 40 (16.5) | 167 (68.7) | |
| Extrathyroid extension | <0.001 | ||
| Yes, n (%) | 103 (43.6) | 44 (18.1) | |
| No, n (%) | 133 (56.3) | 188 (81.9) | |
| Gender | 0.126 | ||
| Male, n (%) | 74 (30.5) | 58 (23.9) | |
| Female, n (%) | 169 (69.5) | 185 (76.1) | |
| Focus | 0.013 | ||
| Unifocal, n (%) | 143 (59.8) | 114 (48.1) | |
| Multifocal, n (%) | 96 (40.2) | 123 (51.9) | |
| T stage | <0.001 | ||
| T1–T2, n (%) | 124 (23.2) | 176 (34.2) | |
| T3–T4, n (%) | 117 (41.1) | 67 (25.9) | |
| N stage | <0.001 | ||
| N0, n (%) | 88 (39.1) | 134 (63.2) | |
| N1, n (%) | 137 (60.9) | 78 (36.8) | |
| M stage | 0.738 | ||
| M0, n (%) | 153 (96.8) | 122 (97.6) | |
| M1, n (%) | 5 (3.2) | 3 (2.4) | |
| Pathologic stage | <0.001 | ||
| I–II, n (%) | 143 (53.1) | 184 (60.7) | |
| III–IV, n (%) | 100 (26.7) | 58 (17.4) | |
| Lymph node metastasis | <0.001 | ||
| Yes, n (%) | 137 (56.4) | 78 (32.1) | |
| No, n (%) | 106 (43.6) | 165 (67.9) | |
| Hashimoto’s thyroiditis | 0.340 | ||
| Yes, n (%) | 31 (14.8) | 40 (18.2) | |
| No, n (%) | 179 (85.2) | 180 (81.8) | |
Abbreviations: MUC1, mucin 1; PTC, papillary thyroid cancer; TCGA, The Cancer Genome Atlas.