Table 8.
Correlation between MUC1 expression and BRAF status in 486 PTC patients from TCGA database
| Variables |
MUC1 (+) BRAF (+) n=203 |
MUC1 (+) BRAF (−) n=40 |
MUC1 (−) BRAF (+) n=76 |
MUC1 (−) BRAF (−) n=167 |
P-valuea | P-valueb | P-valuec | P-valued |
|---|---|---|---|---|---|---|---|---|
| Size (cm) | 2.9±1.7 | 3.0±1.6 | 2.6±1.6 | 2.8±1.6 | 0.817 | 0.337 | 0.062 | 0.521 |
| Age (years) | 48.8±16.0 | 42.3±16.6 | 44.7±12.8 | 47.8±16.3 | 0.021 | 0.136 | 0.046 | 0.055 |
| Extrathyroid extension | 0.378 | 0.021 | 0.009 | 0.002 | ||||
| Yes, n (%) | 89 (44.9) | 14 (36.8) | 21 (27.6) | 23 (14.7) | ||||
| No, n (%) | 109 (55.1) | 24 (63.2) | 55 (72.4) | 133 (85.3) | ||||
| Gender | 0.188 | 0.748 | 0.363 | 0.075 | ||||
| Male, n (%) | 58 (28.6) | 16 (40) | 17 (22.4) | 41 (24.6) | ||||
| Female, n (%) | 145 (71.4) | 24 (60) | 59 (77.6) | 126 (75.4) | ||||
| Lymph node metastasis | 1 | <0.001 | 0.396 | <0.001 | ||||
| Yes, n (%) | 113 (60.8) | 24 (61.5) | 39 (54.9) | 39 (27.6) | ||||
| No, n (%) | 73 (39.2) | 15 (38.5) | 32 (45.1) | 102 (72.3) |
Notes: MUC1 (+) = high expression of MUC1, MUC1 (−) = low expression of MUC1, BRAF (+) = BRAF mutation, BRAF (−) = BRAF wild type.
a
P value represents MUC1 (+) BRAF (+) versus MUC1 (+) BRAF (−).
b
P value represents MUC1 (−) BRAF (+) versus MUC1 (−) BRAF (−).
c
P value represents MUC1 (+) BRAF (+) versus MUC1 (−) BRAF (+).
d
P value represents MUC1 (+) BRAF (−) versus MUC1 (−) BRAF (−).
Abbreviations: MUC1, mucin 1; PTC, papillary thyroid cancer; TCGA, The Cancer Genome Atlas.