Table 3.
Relative risk of PD in individuals with PD-affected first-degree relatives compared with the general population of Taiwan
| Type of affected relative | Sex of affected relative | Sex of individual | Number of individuals with PD | Prevalence (%) | Adjusted relative risksa (95% CIs) |
|---|---|---|---|---|---|
| Any | Male | Male | 200 | 0.41 | 1.65 (1.42–1.93)b |
| Female | 182 | 0.56 | 1.82 (1.58–2.09)b | ||
| All | 382 | 0.47 | 1.73 (1.56–1.92)b | ||
| Female | Male | 317 | 0.64 | 1.71 (1.54–1.90)b | |
| Female | 132 | 0.47 | 1.63 (1.32–2.00)b | ||
| All | 449 | 0.58 | 1.68 (1.52–1.85)b | ||
| All | Male | 498 | 0.51 | 1.66 (1.52–1.82)b | |
| Female | 310 | 0.52 | 1.74 (1.54–1.96)b | ||
| All | 808 | 0.52 | 1.69 (1.56–1.83)b | ||
| Parent | Male (father) | Male | 152 | 0.32 | 1.70 (1.46–1.99)b |
| Female | 51 | 0.17 | 1.50 (1.14–1.97)b | ||
| All | 203 | 0.26 | 1.65 (1.44–1.89)b | ||
| Female (mother) | Male | 286 | 0.59 | 1.66 (1.48–1.86)b | |
| Female | 88 | 0.33 | 1.49 (1.21–1.83)b | ||
| All | 374 | 0.5 | 1.60 (1.45–1.77)b | ||
| All | Male | 419 | 0.45 | 1.64 (1.49–1.80)b | |
| Female | 135 | 0.24 | 1.48 (1.25–1.75)b | ||
| All | 554 | 0.37 | 1.59 (1.47–1.73)b | ||
| Offspring | Male (son) | Male | 34 | 3.82 | 1.33 (0.96–1.84) |
| Female | 122 | 7.24 | 1.98 (1.67–2.34)b | ||
| All | 156 | 6.06 | 1.79 (1.54–2.08)b | ||
| Female (daughter) | Male | 22 | 5.19 | 2.26 (1.52–3.36)b | |
| Female | 41 | 5.81 | 1.94 (1.45–2.59)b | ||
| All | 63 | 5.58 | 2.03 (1.61–2.57)b | ||
| All | Male | 56 | 4.27 | 1.59 (1.24–2.04)b | |
| Female | 163 | 6.83 | 1.97 (1.71–2.28)b | ||
| All | 219 | 5.92 | 1.86 (1.63–2.11)b | ||
| Sibling | Male (brother) | Male | 12 | 0.89 | 1.87 (0.88–3.96) |
| Female | 9 | 0.88 | 2.00 (1.04–3.87)b | ||
| All | 21 | 0.89 | 1.92 (1.15–3.20)b | ||
| Female (sister) | Male | 9 | 1.42 | 2.87 (1.50–5.48)b | |
| Female | 3 | 0.61 | 3.47 (0.84–14.36) | ||
| All | 12 | 1.07 | 2.97 (1.62–5.45)b | ||
| All | Male | 21 | 1.06 | 2.20 (1.32–3.66)b | |
| Female | 12 | 0.79 | 2.23 (1.21–4.12)b | ||
| All | 33 | 0.94 | 2.20 (1.41–3.45)b | ||
| Twin | Male (brother) | Male | 4 | 40 | 71.40 (19.14–266.34)b |
| Female | N/A | N/A | N/A | ||
| All | 4 | 36.36 | 66.63 (17.24–257.48)b | ||
| Female (sister) | Male | N/A | N/A | N/A | |
| Female | N/A | N/A | N/A | ||
| All | N/A | N/A | N/A | ||
| All | Male | 4 | 40 | 71.40 (19.14–266.34)b | |
| Female | N/A | N/A | N/A | ||
| All | 4 | 26.67 | 63.12 (16.45–242.16)b | ||
| Spouse | All | 3,225 | 4.7 | 1.46 (1.41–1.52)b |
Notes:
a
Adjusted for age, sex, place of residence, income levels, occupation, and family size.
b
p<0.05. N/A: no PD cases in affected twin.
Abbreviations: N/A, not applicable; PD, Parkinson’s disease.