Table 4.

The association of rs7248320 with lung cancer risks and non-small-cell lung cancer risks in female and male populations

Genotype and gender	Controls (%) (n=588)	Lung cancer					Non-small cell lung cancer
		Cases (%)(n=512)	OR (95% CI)	P-value	ORª (95% CI)	Pa-value	Cases (%)(n=377)	OR (95% CI)	P-value	ORª (95% CI)	Pa-value
Female
AA	152 (37.9)	136 (39.8)	1.00 (ref)				107 (38.2)	1.00 (ref)
GA	184 (45.9)	165 (48.2)	1.002 (0.733–1.370)	0.989	1.006 (0.735–1.376)	0.973	141 (50.4)	1.089 (0.782–1.515)	0.615	1.108 (0.795–1.545)	0.544
GG	65 (16.2)	41 (12.0)	0.705 (0.448–1.110)	0.131	0.708 (0.449–1.116)	0.136	32 (11.4)	0.699 (0.428–1.142)	0.153	0.705 (0.431–1.152)	0.163
GG+GA vs AA			0.925 (0.688–1.243)	0.604	0.928 (0.689–1.248)	0.620		0.987 (0.721–1.352)	0.953	1.002 (0.731–1.374)	0.989
GG vs GA+AA			0.704 (0.462–1.072)	0.102	0.706 (0.463–1.075)	0.105		0.667 (0.424–1.050)	0.08	0.666 (0.422–1.049)	0.08
A allele	488 (60.8)	437 (63.9)	1.00 (ref)				355 (63.4)	1.00 (ref)
G allele	314 (39.2)	247 (36.1)	0.878 (0.711–1.085)	0.228			205 (36.6)	0.897 (0.718–1.122)	0.341
Male
AA	83 (44.4)	59 (34.7)	1.00 (ref)				38 (39.2)	1.00 (ref)
GA	75 (40.1)	87 (51.2)	1.632 (1.036–2.571)	0.035	1.554 (0.957–2.524)	0.075	49 (50.5)	1.427 (0.843–2.415)	0.185	1.299 (0.740–2.283)	0.362
GG	29 (15.5)	24 (14.1)	1.164 (0.617–2.198)	0.639	1.018 (0.520–1.992)	0.958	10 (10.3)	0.753 (0.333–1.701)	0.495	0.649 (0.276–1.530)	0.324
GG+GA vs AA			1.501 (0.979–2.303)	0.063	1.397 (0.886–2.202)	0.15		1.239 (0.752–2.042)	0.4	1.110 (0.651–1.892)	0.702
GG vs GA+AA			0.896 (0.499–1.609)	0.712	0.803 (0.433–1.491)	0.488		0.626 (0.291–1.346)	0.23	0.566 (0.253–1.263)	0.165
A allele	241 (64.4)	205 (60.3)	1.00 (ref)				125 (64.4)	1.00 (ref)
G allele	133 (35.6)	135 (39.7)	1.193 (0.881–1.616)	0.253			69 (35.6)	1.000 (0.696–1.437)	0.999

Note:

^aAdjusted for age, gender, and smoking.

Abbreviations: CI, confidence interval; OR, odds ratio; ref, reference.