Table 5.

Stratified analyses of rs7248320 with lung cancer risks and non-small-cell lung cancer risks by smoking status

Genotype and smoking status	Controls (%) (n=588)	Lung cancer					Non-small-cell lung cancer
		Cases (%) (n=512)	OR (95% CI)	P-value	ORª (95% CI)	Pa-value	Cases (%)(n=377)	OR (95% CI)	P-value	ORª (95% CI)	Pa-value
Never smoking
AA	188 (40.3)	142 (38.6)	1.00 (ref)				113 (37.9)	1.00 (ref)
GA	204 (43.7)	182 (49.5)	1.181 (0.879–1.588)	0.27	1.180 (0.876–1.588)	0.277	151 (50.7)	1.231 (0.899–1.686)	0.194	1.213 (0.883–1.666)	0.234
GG	75 (16.1)	44 (12.0)	0.777 (0.505–1.196)	0.251	0.776 (0.503–1.197)	0.252	34 (11.4)	0.754 (0.473–1.204)	0.237	0.742 (0.463–1.190)	0.216
GG+GA vs AA			1.072 (0.811–1.419)	0.624	1.071 (0.808–1.419)	0.633		1.103 (0.819–1.487)	0.519	1.086 (0.803–1.469)	0.591
GG vs GA+AA			0.710 (0.476–1.059)	0.093	0.710 (0.475–1.061)	0.095		0.673 (0.436–1.039)	0.074	0.668 (0.431–1.035)	0.071
A allele	580 (62.1)	466 (63.3)	1.00 (ref)				377 (63.3)	1.00 (ref)
G allele	354 (37.9)	270 (36.7)	0.949 (0.777–1.159)	0.61			219 (36.7)	0.952 (0.769–1.177)	0.649
Smoking
AA	47 (38.8)	53 (36.8)	1.00 (ref)				32 (40.5)	1.00 (ref)
GA	55 (45.5)	70 (48.6)	1.129 (0.666–1.914)	0.653	1.047 (0.600–1.826)	0.873	39 (49.4)	1.041 (0.567–1.914)	0.896	0.971 (0.507–1.859)	0.928
GG	19 (15.7)	21 (14.6)	0.980 (0.470–2.043)	0.957	0.915 (0.426–1.967)	0.821	8 (10.1)	0.618 (0.242–1.584)	0.316	0.600 (0.223–1.612)	0.311
GG+GA vs AA			1.091 (0.663–1.795)	0.733	1.012 (0.599–1.710)	0.964		0.933 (0.523–1.665	0.814	0.874 (0.472–1.621)	0.670
GG vs GA+AA			0.917 (0.467–1.798)	0.8	0.893 (0.443–1.799)	0.751		0.605 (0.251–1.458)	0.263	0.610 (0.242–1.535)	0.294
A allele	149 (61.6)	176 (61.1)	1.00 (ref)				103 (65.2)	1.00 (ref)
G allele	93 (38.4)	112 (38.9)	1.020 (0.718–1.448)	0.914			55 (34.8)	0.856 (0.564–1.299)	0.464

Note:

^aAdjusted for age, gender, and smoking.

Abbreviations: CI, confidence interval; OR, odds ratio; ref, reference.