Table 6.

Stratified analyses of rs7248320 with lung cancer risk and non-small-cell lung cancer risk by age

Genotype and age	Controls (%)(n=614)	Lung cancer					Non-small-cell lung cancer
		Cases (%)(n=434)	OR (95% CI)	P-value	ORª (95% CI)	Pa-value	Cases (%)	OR (95% CI)	P-value	ORª (95% CI)	Pa-value
≤60 years
AA	129 (40.4)	106 (37.6)	1.00 (ref)				69 (35.9)	1.00 (ref)
GA	142 (44.5)	135 (47.9)	1.157 (0.816–1.640)	0.412	1.104 (0.770–1.583)	0.590	96 (50.0)	1.264 (0.855–1.868)	0.24	1.122 (0.747–1.685)	0.578
GG	48 (15.0)	41 (14.5)	1.040 (0.637–1.696)	0.877	0.916 (0.553–1.519)	0.735	27 (14.1)	1.052 (0.604–1.831)	0.859	0.917 (0.516–1.629)	0.768
GG+GA vs AA			1.127 (0.811–1.566)	0.475	1.055 (0.751–1.482)	0.757		1.210 (0.836–1.752)	0.312	1.070 (0.728–1.572)	0.732
GG vs GA+AA			0.960 (0.612–1.509)	0.861	0.868 (0.545–1.384)	0.553		0.924 (0.555–1.538)	0.761	0.859 (0.508–1.455)	0.573
A allele	400 (62.7)	347 (61.5)	1.00 (ref)				234 (60.9)	1.00 (ref)
G allele	238 (37.3)	217 (38.5)	1.051 (0.832–1.327)	0.676			150 (39.1)	1.077 (0.830–1.398)	0.575
>60 years
AA	106 (39.4)	89 (38.7)	1.00 (ref)				76 (41.1)	1.00 (ref)
GA	117 (43.5)	117 (50.9)	1.191 (0.814–1.743)	0.368	1.138 (0.769–1.682)	0.518	94 (50.8)	1.121 (0.751–1.673)	0.578	1.104 (0.733–1.663)	0.636
GG	46 (17.1)	24 (10.4)	0.621 (0.352–1.097)	0.101	0.621 (0.348–1.111)	0.108	15 (8.1)	0.455 (0.237–0.87)4	0.018	0.456 (0.235–0.887)	0.021
GG+GA vs AA			1.030 (0.718–1.478)	0.871	0.993 (0.685–1.438)	0.970		0.933 (0.637–1.366)	0.720	0.921 (0.624–1.361)	0.681
GG vs GA+AA			0.565 (0.333–.958)	0.034	0.579 (0.338–0.994)	0.048		0.428 (0.231–0.792)	0.007	0.433 (0.231–0.811)	0.009
A allele	329 (61.2)	295 (64.1)	1.00 (ref)				246 (66.5)	1.00 (ref)
G allele	209 (38.8)	165 (35.9)	0.880 (0.681–1.139)	0.333			124 (33.5)	0.793 (0.602–1.047)	0.101

Note:

^aAdjusted for age, gender, and smoking.

Abbreviations: CI, confidence interval; OR, odds ratio; ref, reference.