Table 7.
Relationship of interaction between rs7248320 and smoking with lung cancer risk and non-small-cell lung cancer risk
| Genotype | Controls (%) (n=588) | Smoking status | Lung Cancer
|
Non-small cell lung cancer
|
||||
|---|---|---|---|---|---|---|---|---|
| Cases (%) (n=512) | ORª (95% CI) | Pa-value | Cases (%) (n=377) | ORª (95% CI) | Pa-value | |||
| GG | 75 (12.8) | Never | 44 (8.6) | 1.00 (ref) | 34 (9.0) | 1.00 (ref) | ||
| GA+AA | 392 (66.7) | Never | 324 (63.3) | 1.420 (0.951–2.121) | 0.086 | 264 (70.0) | 1.499 (0.969–2.319) | 0.069 |
| GG | 19 (3.2) | Ever | 21 (4.1) | 2.110 (0.998–4.459) | 0.050 | 8 (2.1) | 1.176 (0.457–3.026) | 0.736 |
| GA+AA | 102 (17.3) | Ever | 123 (24) | 2.319 (1.416–3.798) | 0.001 | 71 (18.8) | 1.963 (1.134–3.399) | 0.016 |
Note:
a
Adjusted for age, gender, and smoking.
Abbreviations: CI, confidence interval; OR, odds ratio; ref, reference.