Table 8.
Relationship of interaction between rs7248320 and smoking with lung adenocarcinoma risk and lung squamous cell carcinoma risk
| Genotype | Controls (%) (n=588) | Smoking status | Lung adenocarcinoma
|
Lung squamous cell carcinoma
|
||||
|---|---|---|---|---|---|---|---|---|
| Cases (%)(n=258) | ORa (95% CI) | Pa-value | Cases (%) (n=110) | ORa (95% CI) | Pa-value | |||
| GG | 75 (12.8) | Never | 28 (10.9) | 1.00 (ref) | 6 (5.5) | 1.00 (ref) | ||
| GA+AA | 392 (66.7) | Never | 203 (78.7) | 1.377 (0.860–2.204) | 0.182 | 55 (50.0) | 1.810 (0.749–4.375) | 0.188 |
| GG | 19 (3.2) | Ever | 4 (1.6) | 0.863 (0.261–2.849) | 0.809 | 4 (3.6) | 2.369 (0.591–9.502) | 0.224 |
| GA+AA | 102 (17.3) | Ever | 23 (8.9) | 0.970 (0.496–1.896) | 0.928 | 45 (40.9) | 4.846 (1.892–12.416) | 0.001 |
Note:
a
Adjusted for age, gender, and smoking.
Abbreviations: CI, confidence interval; OR, odds ratio; ref, reference.