Figure 1.

Particle size distribution of reference ¹² (A), reference ¹³ (B), reference ¹⁴ (C), reference ¹⁵ (D), and reference ¹⁶ (E) measured by laser diffraction.

Notes: Composition of the engineered nanoparticles – reference ¹²: 400 mg stearic acid, 100 mg cholesteryl oleate, 600 mg octadecylamine, 100 mg poloxamer 188; reference ¹³: 300 mg stearic acid, 200 mg cholesteryl oleate, 600 mg octadecylamine, 100 mg poloxamer 188; reference ¹⁴: 200 mg stearic acid, 300 mg cholesteryl oleate, 600 mg octadecylamine, 100 mg poloxamer 188; reference ¹⁵: 100 mg stearic acid, 400 mg cholesteryl oleate, 600 mg octadecylamine, 100 mg poloxamer 188; reference ¹⁶: 0 mg stearic acid, 500 mg cholesteryl oleate, 600 mg octadecylamine, 100 mg poloxamer 188.

Abbreviation: d, diameter.