Table 1.

Selective effects of Cyp1b1 deletion and GVAD on liver gene expression on the HFD in 14-week old mice

Fold change upper versus	Cyp1b1−/− HFD	GVAD-HFD	R-Cyp1b1−/− LFD
lower	WT BD-HFD	WT BD-HFD	WT BD-LFD
Group A
Acot1	−4.7**	n.s.	n.s.
Cd36	−5.5**	n.s.	2.3
Cyp4a10	−11.1**	−1.9**	n.s.
Lgals1	−5.2**	−1.5*	2.0
Vnn1	−6.1**	−1.5*	n.s.
Pparγ	−4.6**	n.s.	1.6
Egfr	2.2*	n.s.	n.s.
Enho/Adropin	2.0**	2.4**	n.s.
Lifr	3.4**	n.s.	n.s.
Selenbp1	2.5**	n.s.	n.s.
Cyp7b1	4.6*	n.s.	−2.6
Nudt7	2.4**	n.s.	−1.9
Group B
Scd1	−6.0**	−1.5	1.5
Me1	−7.5**	−1.5*	−1.6
Pdk4	−3.7**	−2.0**	n.s.
Igfbp1	−5.1*	n.s.	n.s.
Elovl5	−2.2**	n.s.	n.s.
Osgin1	2.6**	n.s.	n.s.
HF genes
Cyp2c37	n.s.	−2.9**	−2.7
Gadd45	n.s.	5.1**	3.7*
Lpl	1.5	2.7**	2.1
Rbp1	n.s.	3.2**	2.2
Nr0b2/Shp	n.s.	−2.9**	n.s.
Nr1i3/Car	−1.5	−1.8**	−1.5
Sult1b1	n.s.	−1.7*	n.s.

^*p-value ≤ 0.05

^**p-value ≤ 0.01

n.s. Non-significant values where the net FC < 1.5 and p-value > 0.05

Diet: Carbohydrate/Fat/Protein; BD: 55/22/23; HFD: 20/60/20; LFD: 70/10/20