Table 6.
Lipogenic gene expression is not conserved between Cyp1b1−/− and R-Cyp1b1−/− at weaning
| Fold change upper versus | GVAD | Cyp1b1−/− LF12 | R-Cyp1b1−/− LF12 | R-Cyp1b1−/− GVAD |
|---|---|---|---|---|
| lower | LF12 | LF12 | LF12 | R-Cyp1b1−/− LF12 |
| GVAD and Cyp1b1−/− responsive | ||||
| Me1 | −4.1** | −3.6** | n.s. | −1.6 |
| Fasn | −3.3** | −12.2** | n.s. | −1.7 |
| Scd1 | −4.3** | −12.2** | 2.2** | n.s. |
| Elovl6 | −5.3** | −27.8** | n.s. | −2.2 |
| Idi1 | −1.6* | −10.6** | n.s. | −1.6 |
| Cyp51 | −1.9* | −5.8** | n.s. | n.s. |
| Gadd45 | −6.7** | −6.5** | −1.8** | −1.6 |
| Hamp2 | −50.2** | −28.0** | −5.3** | n.s. |
| Hamp | −79.3** | −77.9** | −5.0** | n.s. |
| Shared suppression | ||||
| Acta2 | −2.2** | −2.7** | −3.2** | n.s. |
| Ppp1r3g | −9.4** | −7.3** | −3.4** | n.s. |
| Rgs16 | −3.0** | −5.9** | −2.0* | n.s. |
| Lpin1 | −2.9** | −4.5** | −1.8** | n.s. |
| Egfr | −2.2** | −1.8** | −2.6** | 1.5 |
| Dmbt1 | −6.0** | −25.4** | −14.3** | n.s. |
| Dbp | −1.8 | −5.4** | −5.2* | 2.1 |
| Plk3 | −2.7* | −3.4** | −2.6** | n.s. |
| Ifi27l2b | −2.1* | −3.1** | −2.5** | n.s. |
| Chac1 | −2.7** | −3.0** | −2.3** | n.s. |
| Cyp2s1 | −2.1* | −2.1** | −2.6** | n.s. |
| Cyp1b1−/− selective | ||||
| Gp1ba | n.s. | 2.1** | 1.5* | n.s. |
| Gp9 | n.s. | 3.2** | n.s. | n.s. |
| Tfrc | n.s. | 2.3** | n.s. | n.s. |
| Afp | n.s. | 16.6** | n.s. | n.s. |
| Igf2 | n.s. | 31.9** | n.s. | n.s. |
| H19 | n.s. | 7.5** | 2.1 | −1.9* |
| R-Cyp1b1−/− selective | ||||
| Osgin1 | 1.7* | n.s. | 2.1** | −1.5 |
| Acot1 | n.s. | n.s. | 5.2** | n.s. |
| Cyp7a1 | n.s. | n.s. | −4.9** | 2.3* |
| Nnmt | n.s. | n.s. | −3.7** | n.s. |
*
p-value ≤ 0.05
**
p-value ≤ 0.01
n.s. Non-significant values, FC<1.5 and p-value>0.05