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. 2018 May 28;8:162. doi: 10.3389/fonc.2018.00162

Figure 3.

Figure 3

Agonist treatment of LNCaP cells results in robust metabolomic signatures. The top 15 extracellular metabolites were identified after stimulation with (A) 19-OH AD, (B) acetyl-N-formyl-5-methoxykynurenamine (AFMK), and (C) propionic acid (PA). The top 15 intracellular metabolites were identified after stimulation with (D) 19-OH AD, (E) AFMK, and (F) PA. Heatmaps are based on the Pearson correlation analysis (Ward) and indicate annotated metabolites identified by t-test (P < 0.05, FDR < 0.1, n = 6). Columns correspond to the samples treated with agonists (S1-6) and control (S7-12), and rows correspond to annotated metabolites.