Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 May 28;8:162. doi: 10.3389/fonc.2018.00162

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2018 Abaffy, Bain, Muehlbauer, Spasojevic, Lodha, Bruguera, O’Neal, Kim and Matsunami.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Most pronounced metabolic changes induced by activation of OR51E2 with selected agonists. Venn diagrams show the set of annotated intracellular metabolites differentially expressed by (A) fold change and (B) t-test analysis, and the set of extracellular metabolites identified by (C) fold change and (D) t-test. (E) In total, 36 annotated intracellular metabolites significantly decreased in all three treatments (see Figure 3B). (F) Pathway analysis. The most pronounced pathways in 19-OH AD-treated cells. Pathways are displayed as circles, and the color and size of each circle are based on its P value and pathway impact value, respectively. The top-right area indicates the most significant changes in metabolites. (G) Schematic representation of cellular metabolites. Significantly increased metabolites are in bold red, and significantly decreased are in bold blue (PEP, phosphoenol pyruvate; OAA, oxalacetate; 3PG, 3-phosphoglycerate; α-KG, α-ketoglutarate). Increased neuron-specific enolase (NSE) catalyzes the formation of PEP and is also indicated in red.