Table 3.

Neonatal primary outcomes

	Diet (N = 200)	Metformin (N = 48)	Insulin (N = 101)	Metform vs. diet P	Metform vs.insulin P	Diet vs. insulin P
Birth weight (gr)	3631 ± 650	3496 ± 480	3348 ± 739	NS	NS	< 0.01
Prematurity	13 (6.5%)	2 (4.2%)	20 (19.8%)	NS	< 0.01	< 0.01
LGA (> 2SD/%)	59 (29.5%)	6 (12.5%)	22 (21.7%)	< 0.05	< 0.05	NS
SGA (< 2SD/%)	8 (4%)	3 (6.2%)	14 (13.8%)	NS	NS	< 0.01
Neonatal glycaemia (mean, % with hypoglycae-mia)	3.3 ± 1.2 (24%)	2.8 ± 1.1 (35.4%)	2.6 ± 1.1 (51.5%)	< 0.05 < 0.05	< 0.05 < 0.05	< 0.01 < 0.01
Apgar score at 5’	8.9 ± 0.7	8.6 ± 0.7	8.6 ± 0.8	NS	NS	NS

LGA-large for gestational age; SGA-smgroups for gestational age; SD-standard deviation.