Table 3.
In vivo antidiarrhoeal activity
Compound | Dosage (mg/kg) | The proportion of Weight of Watery Stool (%) | The onset of Diarrhoea (hour) | Total Number of Stools | Number of Watery Stool | Inhibition of Defecation (%) | Inhibition of Diarrhoea (%) |
---|---|---|---|---|---|---|---|
Control | - | 83.07 ± 5.98 | 1.83 ± 0.31 | 16.33 ± 1.50 | 13.17 ± 2.06 | 0.0 | 0.0 |
Loperamide | 4.2 | 42.49 ± 14.57* | 3.67 ± 0.56* | 6.83 ± 2.75* | 3.83 ± 1.72** | 58.16 | 70.89 |
EEZJ | 400 | 77.34 ± 3.70ns | 2.33 ± 0.21ns | 11.17 ± 1.90ns | 9.00 ± 0.97ns | 31.63 | 31.66 |
EEZJ | 800 | 73.00 ± 3.90ns | 2.33 ± 0.33ns | 10.50 ± 1.38ns | 8.67 ± 1.01ns | 35.70 | 34.17 |
EEZJ | 1200 | 66.23 ± 12.06ns | 2.83 ± 0.48ns | 8.50 ± 1.82* | 4.33 ± 1.45** | 47.95 | 67.09 |
(means ± S.E.M; n = 6); ns P ≥ 0.05 compared to control (One-way ANOVA followed by Dunnett’s Test);
P ≤ 0.05 compared to control (One-way ANOVA followed by Dunnett’s Test);
P ≤ 0.01 compared to control (One-way ANOVA followed by Dunnett’s Test.