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. 2018 Jun 1;27(11):723–735. doi: 10.1089/scd.2018.0002

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Copyright 2018, Mary Ann Liebert, Inc.

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FIG. 2. — Quantitative mass spectrometry analysis of human ovarian tissue lysates. (A) A Venn diagram shows overlap of proteins detected by label-free quantitative mass spectrometry (3,837 total detected) for fetal tissue from developmental days 47, 108, 122, or 137 and adult reproductive aged tissue. (B) Quantitative mass spectrometry detection of germ cell proteins DAZL, DDX4, DAZAP1, YBX2, and SYCP3 at four stages of fetal development (days 47, 108, 122, and 137) and in a representative adult tissue sample presented as fold change compared to tissue from 137 days of development. (C) A Venn diagram illustrates the proteins detected in day 47 and day 137 fetal tissue with restrictive bioinformatics processing to detect only highly differentially expressed proteins; significantly upregulated pathways are specified. EGF, epidermal growth factor; LXR/RXR, liver X receptor/retinoic acid receptor pathway.