. Author manuscript; available in PMC: 2018 Jul 1.

Published in final edited form as: Nat Genet. 2017 Dec 18;50(1):6–11. doi: 10.1038/s41588-017-0013-8

Table 1. Fifteen independent SNPs associated with neuroticism in UK Biobank most strongly replicated (with consistent allelic effect) in the meta-analysis of 23andMe and the GPC cohorts. Bolded genes were significant in the gene-based tests.

Chr	SNP	MAF	Discovery P-value (N=329,821)	Replication P-value (N=122,867)	Nearest Gene	Distance to Gene	Genes within Range	Significant in Previous GWA Studies
1	rs169235	.25	3.97×10^-9	2.55E-05	CACNA1E^**	0
5	rs1422192^{^}	.17	1.68×10^-9	6.54E-07	LINC00461	0	MEF2C^**
8^*^ǂ	rs2921036	.49	8.04×10^-26	3.27E-07	.	.	CLDN23, ERI1^, MFHAS1^, SGK223
8^*^ǂ	rs2953805	.47	3.02×10^-22	1.26E-08	U3	1292	CLDN23, ERI1^, MFHAS1^, PPP1R3B	Morning vs Evening Chronotype ²⁴
8^*^ǂ	rs6982308	.49	6.46×10^-21	2.26E-08	MSRA^**	0
8^*^ǂ	rs7005884	.45	1.92×10^-23	1.34E-07	XKR6	0	C8orf74, PINX1^, PRSS55^, RP1L1, SOX7^, XKR6**
8^*^ǂ	rs10097870	.47	2.18×10^-24	6.51E-07	LINC00208	5665	BLK^, CTSB^, DEFB134^*, DEFB135, DEFB136, FAM167A^, FDFT1, GATA4, LOC100133267, MTMR9, NEIL2, SLC35G5, XKR6*
9	rs1521732	.37	2.91×10^-9	4.01E-06	LINGO2	0
9	rs72694263	.08	2.12×10^-8	0.000237	.	.
11^*	rs7107356	.50	1.52×10^-12	1.34E-05	AGBL2	4973	ACP2, AGBL2, C1QTNF4, CELF1, DDB2^, FAM180B, FNBP4^, KBTBD4, MADD^, MTCH2^, MYBPC3, NDUFS3, NR1H3, NUP160^, PSMC3, PTPMT1, RAPSN, SLC39A13^, *SPI1*	Neuroticism ⁴
11^*	rs7111031	.36	1.06×10^-15	0.000215	.	.	*DRD2*
15^*	rs7175083	.48	1.16×10^-9	0.000297	LINGO1	0
17	rs7502590	.15	2.61×10^-11	0.000146	BAIAP2	0	AATK, BAIAP2
18^*	rs11082011	.34	1.25×10^-16	2.05E-06	CELF4	0
22^*	rs11090045	.30	8.04×10^-13	5.40E-07	ZC3H7B^**	0	ACO2, C22orf46, CHADL, CSDC2^, DESI1, EP300, L3MBTL2^, MEI1, NHP2L1, PHF5A, PMM1, POLR3H, RANGAP1^, RBX1, TEF^, TOB2, XRCC6, ZC3H7B^**

^{^}

Genotyped SNP

^ǂ

Located in Inversion Region

Broad region implicated in previous studies ⁴,²²,⁴⁵

^**

Regulated gene expressed in brain