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. Author manuscript; available in PMC: 2018 Nov 15.
Published in final edited form as: J Immunol. 2018 May 15;200(10):3333–3339. doi: 10.4049/jimmunol.1800120

Figure 2. Cytokine Production By Intrathymic iNKT2 Cells Controls Conventional Thymocyte Egress Via The Type 2 IL4R.

Figure 2

In wildtype (WT) mice, IL4/IL13 production by type 2 iNKT-cells triggers Type 2 IL4R in signalling in mTEC for normal transit of fully mature conventional thymocytes from the medulla to the circulation via the perivascular space (PVS). While the downstream mediators of this process are not known, IL4Rα signalling in mTEC is known to trigger the expression of chemokines that include CXCL10 and CCL21. In IL4Rα-/- mice, lack of type 2 IL4R signalling in thymic stroma results in the intrathymic accumulation of mature thymocytes within the PVS, and a reduction in recent thymus emigrants (RTE).