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. Author manuscript; available in PMC: 2018 Jun 4.
Published in final edited form as: Results Probl Cell Differ. 2017;59:175–200. doi: 10.1007/978-3-319-44820-6_6

Fig. 6.4.

Fig. 6.4

Translational control of the self-renewal/differentiation decision in the Drosophila ovary. In the Drosophila ovary, signaling from the niche (cap cells) suppresses bam transcription in the GSC. Apart from this, Nos-Pum pair represses the translation of brat, mei-P26, and other unknown mRNAs to prevent premature differentiation. The GSC divides such that one daughter cell is oriented away from the niche and does not receive sufficient niche signals to suppress bam. Bam forms a multi-protein complex with Mei-P26, Sex-lethal, and BGCN and suppresses nos translation. Absence of Nos derepresses the brat mRNA leading to Brat expression, which partners with Pum and inhibits the translation of dMyc, Mad, Medea, and Schnurri to promote differentiation