Table 3.
Associations of genetic risk scores with MRI adiposity measures in males (N=979) and females (N=1 016) separately a,b
| Risk score | SAT | VAT | VAT/SAT ratio | Liver fat fraction | Pericardial fat mass | BMI @ 10 | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| (number of SNPs in risk score) | Beta (CI 95%) | P | Beta (CI 95%) | P | Beta (CI 95%) | P | Beta (CI 95%) | P | Beta (CI 95%) | P | Beta (CI 95%) | P |
| Males | N=856 | N=851 | N=851 | N=958 | N=884 | N=977 | ||||||
| Childhood BMI (N=15) | 0.024 | 0.004 | 0.022 | 0.013 | -0.008 | 0.301 | 0.015 | 0.052 | -0.005 | 0.545 | 0.038 | 9.00*10-6 |
| (0.008; 0.040) | (0.005; 0.040) | (-0.023; 0.007) | (0.000; 0.031) | (-0.022; 0.012) | (0.021; 0.054) | |||||||
| Adult BMI (N=97) | 0.025 | 1.00*10-6 | 0.018 | 0.001 | -0.015 | 0.002 | 0.007 | 0.167 | 0.010 | 0.061 | 0.029 | 5.95*10-8 |
| (0.015; 0.035) | (0.007; 0.029) | (-0.025; -0.006) | (-0.003; 0.017) | (0.000; 0.021) | (0.018; 0.039) | |||||||
| Adult WHR (N=49) | -0.009 | 0.214 | -0.004 | 0.596 | 0.006 | 0.390 | -0.003 | 0.695 | -0.012 | 0.123 | -0.013 | 0.078 |
| (-0.024; 0.005) | (-0.020; 0.011) | (-0.008; 0.019) | (-0.016; 0.011) | (-0.027; 0.003) | (-0.028; 0.001) | |||||||
| VAT/SAT ratio (N=3)* | 0.028 | 0.329 | 0.019 | 0.549 | -0.017 | 0.525 | -0.014 | 0.598 | 0.006 | 0.838 | 0.023 | 0.442 |
| (-0.029; 0.085) | (-0.042; 0.080) | (-0.070; 0.036) | (-0.068; 0.039) | (-0.053; 0.065) | (-0.035; 0.081) | |||||||
| Adult fatty liver (N=5) | 0.033 | 0.202 | 0.024 | 0.398 | -0.034 | 0.166 | 0.094 | 1.65*10-6 | 0.001 | 0.976 | 0.003 | 0.904 |
| (-0.018; 0.084) | (-0.031; 0.078) | (-0.081; 0.014) | (0.045; 0.143) | (-0.053; 0.055) | (-0.050; 0.057) | |||||||
| Adult pericardial fat (N=3) * | 0.004 | 0.891 | 0.046 | 0.190 | 0.046 | 0.130 | -0.003 | 0.917 | 0.028 | 0.402 | -0.025 | 0.458 |
| (-0.059; 0.069) | (-0.023; 0.114) | (-0.013; 0.105) | (-0.064; 0.057) | (-0.038; 0.095) | (-0.090; 0.040) | |||||||
| rs7185735 (SAT) | 0.106 | 0.028 | 0.075 | 0.148 | -0.068 | 0.130 | 0.046 | 0.312 | 0.075 | 0.137 | 0.071 | 0.155 |
| (0.012; 0.200) | (-0.027; 0.176) | (-0.020; 0.156) | (-0.136; 0.043) | (-0.024; 0.174) | (-0.027; 0.168) | |||||||
| rs2123685 (SAT female) | -0.039 | 0.764 | -0.200 | 0.149 | -0.145 | 0.227 | -0.047 | 0.708 | -0.178 | 0.183 | 0.150 | 0.270 |
| (-0.293; 0.215) | (-0.471; 0.072) | (-0.380; 0.091) | (-0.190; 0.197) | (-0.439; 0.084) | (-0.117; 0.416) | |||||||
| rs2842895 (VAT and VATadjBMI) | 0.001 | 0.981 | -0.036 | 0.487 | -0.031 | 0.489 | -0.036 | 0.432 | 0.025 | 0.614 | -0.010 | 0.837 |
| (-0.093; 0.086) | (-0.138; 0.066) | (-0.119; 0.057) | (-0.054; 0.125) | (-0.073; 0.124) | (-0.107; 0.087) | |||||||
| rs10060123 (VAT and VATadjBMI female) | -0.070 | 0.191 | -0.071 | 0.220 | 0.023 | 0.640 | -0.111 | 0.028 | -0.055 | 0.322 | -0.070 | 0.206 |
| (-0.176; 0.035) | (-0.184; 0.042) | (-0.075; 0.122) | (-0.210; 0.012) | (-0.165; 0.054) | (-0.177; 0.038) | |||||||
| Females | N=890 | N=891 | N=887 | N=992 | N=919 | N=1 016 | ||||||
| Childhood BMI (N=15) | 0.016 | 0.031 | 0.019 | 0.014 | -0.002 | 0.731 | 0.003 | 0.715 | 0.011 | 0.147 | 0.023 | 0.002 |
| (0.001; 0.031) | (0.004; 0.035) | (-0.017; 0.012) | (-0.013; 0.018) | (-0.004; 0.027) | (0.008; 0.038) | |||||||
| Adult BMI (N=97) | 0.018 | 2.65*10-4 | 0.016 | 0.002 | -0.010 | 0.043 | 0.001 | 0.905 | 0.009 | 0.108 | 0.024 | 2.0*10-6 |
| (0.009; 0.028) | (0.006; 0.027) | (-0.020; 0.000) | (-0.010; 0.011) | (-0.002; 0.019) | (0.014; 0.034) | |||||||
| Adult WHR (N=49) | -0.010 | 0.149 | 0.0003 | 0.963 | 0.016 | 0.014 | -0.001 | 0.917 | -0.008 | 0.253 | -0.007 | 0.334 |
| (-0.023; 0.004) | (-0.014; 0.014) | (0.003; 0.029) | (-0.015; 0.013) | (-0.022; 0.006) | (-0.020; 0.007) | |||||||
| VAT/SAT ratio (N=3) * | -0.037 | 0.16 | -0.033 | 0.241 | 0.017 | 0.502 | -0.012 | 0.660 | -0.030 | 0.273 | -0.038 | 0.161 |
| (-0.088; 0.015) | (-0.087; 0.022) | (-0.033; 0.067) | (-0.066; 0.042) | (-0.085; 0.024) | (-0.090; 0.015) | |||||||
| Adult fatty liver (N=5) | -0.033 | 0.198 | -0.021 | 0.432 | 0.025 | 0.318 | 0.148 | 2.09*10-8 | 0.017 | 0.546 | -0.04 | 0.12 |
| (-0.084; 0.017) | (-0.075; 0.032) | (-0.024; 0.074) | (0.097; 0.200) | (-0.036; 0.070) | (-0.091; 0.011) | |||||||
| Adult pericardial fat (N=3) * | -0.045 | 0.147 | 0.004 | 0.905 | 0.063 | 0.038 | -0.007 | 0.834 | 0.100 | 0.002 | -0.024 | 0.434 |
| (-0.106; 0.016) | (-0.061; 0.069) | (0.004; 0.122) | (-0.070; 0.056) | (0.036; 0.164) | (-0.086; 0.037) | |||||||
| rs7185735 (SAT) | 0.197 | 6.00*10-6 | 0.110 | 0.018 | -0.186 | 1.20*10-5 | 0.041 | 0.368 | 0.006 | 0.900 | 0.160 | 3.71*10-4 |
| (0.112; 0.283) | (0.019; 0.201) | (-0.103; -0.269) | (-0.132; 0.049) | (-0.086; 0.098) | (0.072; 0.247) | |||||||
| rs2123685 (SAT female) | -0.034 | 0.788 | -0.138 | 0.298 | -0.103 | 0.397 | 0.193 | 0.132 | 0.085 | 0.621 | 0.034 | 0.787 |
| (-0.279; 0.212) | (-0.399; 0.122) | (-0.341; 0.136) | (-0.059; 0.445) | (-0.192; 0.322) | (-0.212; 0.280) | |||||||
| rs2842895 (VAT and VATadjBMI) | 0.035 | 0.449 | 0.031 | 0.525 | -0.005 | 0.917 | 0.022 | 0.642 | 0.082 | 0.092 | 0.050 | 0.283 |
| (-0.055; 0.124) | (-0.064; 0.126) | (-0.092; 0.082) | (-0.115; 0.071) | (-0.013; 0.177) | (-0.041; 0.141) | |||||||
| rs10060123 (VAT and VATadjBMI female) | -0.027 | 0.596 | -0.066 | 0.216 | -0.047 | 0.337 | 0.049 | 0.351 | -0.078 | 0.142 | -0.040 | 0.433 |
| (-0.125; 0.072) | (-0.170; 0.039) | (-0.142; 0.049) | (-0.054; 0.151) | (-0.182; 0.026) | (-0.140; 0.060) |
a
Analyses were performed in children with complete data on genetic variants and covariates and at least one outcome under study
b
Values are linear regression coefficients for models adjusted for sex, age, and the first four principal components and represent the difference in standard deviation scores of the outcome measures for each additional average risk allele in the risk scores.
Bold values represent nominally significant outcomes
*
Unweighted risk scores since no information on the effect estimates was available. Bold values represent significant outcomes after Bonferroni correction for 10 analyses (P<0.005)