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. Author manuscript; available in PMC: 2018 Jun 4.
Published in final edited form as: Inorg Chem. 2016 Jun 14;55(13):6364–6375. doi: 10.1021/acs.inorgchem.6b01034

Figure 11.

Figure 11

Geometric and electronic structures of the resting multicopper oxidases. (A) Geometric structure.41 The electron from substrate enters at T1 and is transferred over 13 Å to the TNC where O2 is reduced to water. The TNC has an OH− bridged AF coupled T3 Cu(II) pair with no EPR signal and a localized T2 Cu(II) at 3.5 Å from the T3 Cu’s with a normal EPR signal in the resting enzyme. (B) Results of spectroscopic and electronic structure calculations (ref 40) showing that all three Cu’s of the resting TNC have open coordination positions oriented toward the center of the cluster enabling bridged O2 intermediates.