Table 1.

Conserved and FSPs in the aspartate aminotransferase superfamily. One column of the table represents one column of the multiple alignment of the aspartate aminotransferase superfamily enzymes. N/A, no equivalent (i.e., a gap in the multiple alignment)

Functional family	PDBa	Conserved positions			FSPs
l‐allo‐threonine aldolase	3wgb	D168	K199	R313	G60	T61	N64	H85	E138	A170	R171	C196	S198	G200	K224	R231
Serinehydroxymethyltransferase	2w7e	D197	K226	R357	G94	A95	N98	H122	A171	A199	H200	T223	H225	T227	Q255	Y51
2‐amino‐3‐ketobutyrate‐CoA ligase	3a2b	D210	K244	R367	G113	F114	N117	H138	D181	A212	H213	T241	S243	S245	F272	N85
Cystathionine β‐lyase	1ibj	D253	K278	R440	G157	M158	L161	Y181	E224	S255	I256	S275	T277	F279	N307	R129
Threoninephosphate decarboxylase	1lkc	D185	K216	R337	E85	T86	I89	F108	C153	A187	F188	S233	T215	F217	M244	Y56
l‐low specificity‐threonine aldolase	1v72	D174	K207	R327	G64	T65	N68	H89	T143	S181	R177	G204	T206	N208	K237	Y35
Alanine‐glyoxylate aminotransferase	2bkw	D175	K201	R354	G68	T69	W72	F97	T144	V177	C178	A198	Q200	A202	N/A	Y255
Tryptophanase	2ez2	D214	K257	R404	G99	R100	E103	F123	A171	T216	R217	S254	K256	D258	V283	Y71
Tyrosine aminotransferase	4ix8	D253	K286	R422	V150	S151	I154	F175	I171	I255	Y256	G283	A285	Y287	Q319	Y109
Kynureninase	1qz9	D201	K227	R375	T97	S98	L101	F129	T172	A203	H204	C224	Y226	Y228	N/A	Y226
Amine aminotransferase	4ba5	D259	K287	V423 (R416)	G120	S121	V124	Y153	E 226	V261	I262	T284	A286	G288	H318	K288
Acetylornithine aminotransferase	4ade	D222	K252	R374	G105	A106	N109	F138	E190	V225	Q226	T249	A251	A253	N/A	T281
l‐tyrosine decarboxylase	3f9t	D206	K245	R371	G94	T95	N98	H132	I177	A208	F209	D242	H244	M246	N/A	T285
Aspartate aminotransferase	4dbc	D223	K258	R386	G115	T116	L119	W142	H190	A225	Y226	S255	S257	N259	R292	N/A
Protein MalY aminotransferase	1d2f	D201	K233	R365	V96	I97	V100	Y121	C169	I203	H204	S230	S232	S234	K261	Y61

^aThe conserved positions and FSPs are provided for representative proteins in each functional family (the pdb field).