Table 1.
Demographic characteristics and neuropathological findings, according to clinical dementia status.
| No dementia | Dementia | Not Determined | |
|---|---|---|---|
| n | 47 | 69 | 10 |
| Number female (%) | 21 (44) | 47 (68) | 3 (30) |
| Age, median (inter-quartile range) | 82 (76-90) | 89 (85-93) | 84 (77-87) |
| AD pathology present | 8 (17) | 39 (56) | 2 (20) |
| APOEε4 present | 10 | 23 | 0 |
| Braak stage I/II | 23 (49) | 15 (22) | 4 (40) |
| Braak stage III/IV | 12 (26) | 16 (23) | 2 (20) |
| Braak stage V/VI | 1 (2) | 21 (30) | 0 (0) |
| Moderate-severe parenchymal CAA severity | 2 (4) | 10 (14) | 0 (0) |
| Moderate-severe meningeal CAA severity | 5 (11) | 16 (23) | 0 (0) |
Unless otherwise stated, data shown are number of participants (%). AD: Alzheimer’s disease, CAA: cerebral amyloid angiopathy. APOE genotype, data available for n=108 participants. Braak stage and CAA severity are defined in Supplementary Methods, Neuropathological Assessment.